All products

%
Julabo CORIO CD-300F Refrigerated/heating circulator
Refrigerated / Heating Circulators of the CORIO series distinguish themselves with a great price-performance ratio. They are ideal for all standard tasks and routine work in laboratories and industry.
• Models for internal and external applications
• Bright, white, easy-to-read display
• Very quiet
• Easy change-over from internal to external circulation and vice versa
• External pump connections (M16×1)
• USB interface
• Space-saving cooling coil design provides more usable space in the bath tank
• Bath lid and drain tap included
• Removable ventilation grid
• Refrigeration unit without side vents
• Class III (FL) according to DIN 12876-1
To adapt the CORIO Refrigerated / Heating Circulator to your individual application, we offer a comprehensive range of accessories (bath fluid, tubing, adapter and more).
%
Julabo CORIO CD-310F Refrigerated/heating circulator
Refrigerated / heating circulators of the CORIO series distinguish themselves with a great price-to-performance ratio. They are ideal for all standard tasks and routine work in laboratories and industry.
Product features:
• Models for internal and external applications
• Bright, white, easy-to-read display
• Very quiet
• Easy change-over from internal to external circulation and vice versa
• Integrated pump connection (M16×1)
• USB connection
• Space-saving cooling coil design provides more usable space in the bath tank
• Bath lid and drain tap included
• Removable ventilation grid
• Refrigeration unit without side vents
• Class III (FL) according to DIN 12876-1
%
Miele PLW 8693 [DS5 CM MON] SST Laboratory washer
Laboratory dishwasher with liquid dispensing, DryPlus hot air drying and monitoring package
• Construction type: Freestanding, can be builtunder, slimline
• Casing: Stainless Steel
• In-door salt container
• AutoClose – automatic door lock
• Buzzer, acoustic signal at end of programme
Control system
• Control type: M Touch Flex, full-touch colour display
• Programmable
• Programme sequence display, selectable display languages
Standard electrical connection
• Electrical connection: 3N AC 400V 50HZ
• Total rated load in kW: 9,30
Water connection/drainage
• Cold water [number]: 1
• Hot water [number]: 1
• DI water [number]: 1
• Required flow pressure in kPa: 200-1000
Drying unit
• Air throughput in m³/h: 60
• HEPA filter class H13, HEPA filter filtration efficiency (in accordance with DIN EN1822) in %: >99,95
• Heat dissipation into the room in MJ/h: 5,40
Features
• 1 dispenser pump for liquid cleaning agent
• Suction lance for media canisters 10–20 l (optional)
• DS5 Flex suction lance
• Spray pressure and spray arm monitoring
• DryPlus - Efficient hot air drying
• Chamber lighting
• Variable-speed heater pump
• Wash cabinet made from high-quality stainless steel (1.4301/304)
Connection options
• External dispensing modules
%
Julabo CORIO CD-310F Refrigerated/heating circulator with natural refrigerant
Refrigerated / heating circulators of the CORIO series distinguish themselves with a great price-to-performance ratio. They are ideal for all standard tasks and routine work in laboratories and industry.
Product features:
• Models for internal and external applications
• Bright, white, easy-to-read display
• Very quiet
• Easy change-over from internal to external circulation and vice versa
• Integrated pump connection (M16×1)
• USB connection
• Space-saving cooling coil design provides more usable space in the bath tank
• Bath lid and drain tap included
• Removable ventilation grid
• Refrigeration unit without side vents
• Class III (FL) according to DIN 12876-1
• Refrigerant R290
%
Julabo DYNEO DD-300F Refrigerated/heating circulator
Refrigerated circulators of the DYNEO series distinguish themselves with a great price-performance ratio. The instruments offer high heating/cooling capacities for short heat-up and cool-down times. The refrigerated circulators work precisely and reliably even at higher ambient temperatures up to +40 °C. Either in basic research, in material testing or in technical systems – the DYNEO refrigerated circulators offer functional solutions for every requirement and budget.
• Models suitable for internal and external applications
• Optimized cooling coil design provides more space in the bath
• Continuously adjustable, powerful pressure pump
• Supply pressure 0.7 bar
• Easy change-over from internal to external circulation and vice versa
• Large color TFT display, multi-lingual user interface
• Ease of use via central rotary dial
• Integrated programmer
• External Pt100 sensor connection
• USB data port
• RS232 interface or analog interfaces (optional)
• Built-in drain tap for easy and safe drainage
%
Julabo DYNEO DD-310F Refrigerated/heating circulator
Refrigerated circulators of the DYNEO series distinguish themselves with a great price-performance ratio. The instruments offer high heating/cooling capacities for short heat-up and cool-down times. The refrigerated circulators work precisely and reliably even at higher ambient temperatures up to +40 °C. Either in basic research, in material testing or in technical systems – the DYNEO refrigerated circulators offer functional solutions for every requirement and budget.
• Models suitable for internal and external applications
• Optimized cooling coil design provides more space in the bath
• Continuously adjustable, powerful pressure pump
• Supply pressure 0.7 bar
• Easy change-over from internal to external circulation and vice versa
• Large color TFT display, multi-lingual user interface
• Ease of use via central rotary dial
• Integrated programmer
• External Pt100 sensor connection
• USB data port
• RS232 interface or analog interfaces (optional)
• Built-in drain tap for easy and safe drainage
%
Julabo CORIO CP-310F Refrigerated/heating circulator
Product features:
• Models for internal and external applications
• Bright, white, easy to read display
• Very quiet
• Easy switching between internal and external circulation
• Powerful and infinitely adjustable pressure pump
• Interfaces: R232, USB
• ATC: 3 Point Calibration
• Temperature control: PID1
• Setting the resolution of the LED temperature display °C: 0.1
• Class III (FL) according to DIN 12876-1
• Bath lid and drain tap included
• Removable ventilation grid
• Refrigeration unit without side vents
• Integrated pump connection M16×1
• Space-saving cooling coil design provides more usable space in the bath tank
• Early warning system for low liquid level
%
Miele PLW 8693 [DS5 MON OIL] SST Laboratory washer
Laboratory dishwasher with liquid dispensing, DryPlus hot air drying, oil seals and monitoring
• Construction type: Freestanding, can be builtunder, slimline
• Casing: Stainless Steel
• In-door salt container
• AutoClose – automatic door lock
• Buzzer, acoustic signal at end of programme
Control system
• Control type: M Touch Flex, full-touch colour display
• Programmable
• Programme sequence display, selectable display languages
Standard electrical connection
• Electrical connection: 3N AC 400V 50HZ
• Total rated load in kW: 9,30
Water connection/drainage
• Cold water [number]: 1
• Hot water [number]: 1
• DI water [number]: 1
• Required flow pressure in kPa: 200-1000
Drying unit
• Air throughput in m³/h: 60
• HEPA filter class H13, HEPA filter filtration efficiency (in accordance with DIN EN1822) in %: >99,95
• Heat dissipation into the room in MJ/h: 5,40
Features
• 1 dispenser pump for liquid cleaning agent
• Suction lance for media canisters 10–20 l (optional)
• DS5 Flex suction lance
• Spray pressure and spray arm monitoring
• DryPlus - Efficient hot air drying
• Chamber lighting
• Variable-speed heater pump
• Wash cabinet made from high-quality stainless steel (1.4301/304)
Connection options
• External dispensing modules
%
Binder KBF PRO 260 plant growth chamber with LED plant light module
The Binder KBF PRO 260 climate chamber, with its extended temperature and humidity range, combined with the Binder LED light module, can be easily adapted for plant growth applications. The system provides precise control throughout all growth stages, featuring three independent light channels and real-time programming options to perfectly meet the unique needs of plants.

Package contents

Binder KBF PRO 260 standard climate chamber with extended temperature and humidity range

• Temperature range: +10°C to +50°C
• Humidity range: 10% to 90% relative humidity (RH)
• Proven APT.line™ preheating chamber technology
• Energy-efficient cooling with modern inverter cooling unit
• Cooling with environmentally friendly R-290 refrigerant
• Door heating to prevent condensation
• Adjustable fan speed
• Humidity control with capacitive humidity sensor and rapid steam humidification
• Housing design with HIT technology
• Stainless steel interior
• Interior doors made of safety glass with metal oxide coating
• Two stainless steel shelves with telescopic rails
• Large access port with silicone plug
• Floor-standing design with sturdy twin casters and front brakes
• Stackable desktop models, up to 130 liters in capacity
• Intuitive touch-screen controller with time-segmented and real-time programming
• Internal data logger, measured values can be read in open format via USB
• Independent Class 3.3 temperature safety device (DIN 12880) with visual and acoustic alarms
• Device self-test with comprehensive status analysis
• Data interfaces: Ethernet, USB
• BINDER Multi Management Software APT-COM™ basic version

Binder light module for plant growth

• 16 LED light strips with mounting clips
• Lighting control unit with program controller, power supply, and fresh air pump
• Mounting rails and screws for securing the lighting control unit
• Special silicone foam plugs for sealing the access port
• Cabling

Control unit functions

• Three light channels, individually adjustable from 10% to 100%
• Real-time programming
• Twilight function
• Ventilation function
%
Heidolph Hei-PLATE Sensor Advanced Package Expert (135 mm)
Includes:

• Magnetic stirrer Hei-PLATE Mix'n'Heat Expert (135 mm diameter) - Fast and precise heating - Without overshoot - For sample-friendly work
• Pt1000 temperature sensor for precise temperature regulation
• Pt1000 holder with cable device for securely attaching the temperature sensor
• Silicone protective cover for a longer lasting protection of your magnetic stirrer
• Also available with 145 mm plate on request
%
Julabo CORIO CP-310F Refrigerated/heating circulator with natural refrigerant
Product features:
• Models for internal and external applications
• Bright, white, easy to read display
• Very quiet
• Easy switching between internal and external circulation
• Powerful and infinitely adjustable pressure pump
• Interfaces: R232, USB
• ATC: 3 Point Calibration
• Temperature control: PID1
• Setting the resolution of the LED temperature display °C: 0.1
• Class III (FL) according to DIN 12876-1
• Bath lid and drain tap included
• Removable ventilation grid
• Refrigeration unit without side vents
• Integrated pump connection M16×1
• Space-saving cooling coil design provides more usable space in the bath tank
• Early warning system for low liquid level
• Refrigerant R290
%
Bandelin SONOREX TECHNIK RM 110 U ultrasonic bath
High-performance ultrasonic cleaner for versatile applications

The proven and particularly robust SONOREX ultrasonic baths clean thoroughly and gently by means of intensive cavitation bubbles, even in the hard-to-reach places of the cleaning objects.

A user-friendly rotary handle control is used for easy adjustment of the cleaning time. Matching baskets, lids and cleaning and disinfection concentrates are available as accessories for optimally coordinated ultrasonic cleaning.

The SONOREX TECHNIK range currently consists of 4 series with common characteristics:

• welded stainless steel cleaning tank, 2 mm
• overflow gutter: combined with an oil separator and or a filtering system to continuously remove dirt, oils and grease floating on the surface of the tank
• cleaning fluid filling level mark, facilitates dosing
• welded drain with three-way ball valve for emptying or filling the tank and connecting a filtration system
• additional drain for connecting an oil separator and draining the overflow gutter
• heating: all models are available with (UH) or without (U) heating: on / off with control indicator, thermostatic, adjustable from 30 to 80 ° C
• case protected against drops of water in stainless steel
• for baskets, possibility of having a motorized lift with agitation function
• possibility of making sets of 2 to 5 stations with ultrasonic bath, rinsing bath, drying tank with a motorized translator / elevator / agitator
• straight tank bottom
• garden tube in the tank opposite the overflow gutter to create a flow on the surface of the bath that drains floating contamination, oils and grease from the surface of the bath into the overflow weir.
• safety float switch as protection for heating and ultrasound against dry running.
• feet adjustable in height for leveling on uneven supports.
• ultrasonic generator (integrated): frequency 40 or 25 kHz
• 40 kHz = more penetrating, 25 kHz = more powerful but noisier
%
Binder FD 260 drying and heating chambers with forced convection
A BINDER FD series Avantgarde.Line heating oven is always used when fast drying and sterilization is required. Thanks to its fully homogeneous temperature distribution, quick dynamics and powerful fan, this heating oven saves valuable time.
Benefits
• Best energy efficiency on the market
• Excellent temporal and spatial temperature accuracy
• USB connection for recording data
• Temperature range up to +300 °C
Important characteristics
• Temperature range: +10 °C above ambient temperature to +300 °C
• High temperature accuracy thanks to APT.line™ technology
• Forced convection
• Controller with LCD display
• Electromechanical control of the exhaust air flap
• 2 chrome-plated racks
• Units up to 115 L are stackable
• Class 2 independent temperature safety device (DIN 12880) with visual temperature alarm
• Ergonomic handle design
• USB port for recording data
%
Nabertherm L 5/13/C550 muffle furnace with brick insulation
Heating elements on support tubes radiating freely into the furnace chamber provide for particularly short heating times for these muffle furnaces. Thanks to their robust lightweight refractory brick insulation, they can reach a maximum working temperature of 1300 °C. These muffle furnaces thus represent an interesting alternative to the familiar L(T) ../12 models, when you need a higher application temperature.

Standard Equipment
• Heating from two sides
• Heating elements on support tubes ensure free heat radiation and a long service life
• Multi-layer insulation with robust lightweight refractory bricks in the furnace chamber
• Dual shell ventilated housing made of textured stainless steel sheets for low surface temperature and high stability
• With flap door (L)
• Adjustable air inlet in the furnace door
• Exhaust air outlet in rear wall of furnace
• Solid state relays provide for lownoise operation
• With Controller C550 (10 programs / 20 steps)

Option
• Chimney, chimney with fan or catalytic converter
• Over-temperature limiter with adjustable cutout temperature as temperature limiter to protect the furnace and load
• Protective gas connection to purge with non-flammable process gases (not available in combination with chimney, chimney with fan or catalytic converter) not gas tight
• Manual or automatic gas supply system
• Port for thermocouple in the rear wall or in the furnace door
%
Esco LA2-6E8-EU G4 Labculture® Plus G4 Class II Biological Safety Cabinet, 6ft/1.8m
The new BSC with Centurion Touchscreen controller is EN 12469-certified and now available in 200 mm (8"") opening, with standby height that easily activates standby mode.

Labculture® Plus G4 (LA2-E-EU G4) ergonomic work zone is comprised of bright illumination using industry-leading dimmable LED lamp combined with raised, durable, stainless-steel armrest and autoclavable, multi-piece work zone devised for optimum work comfort.

Product features:

Centurion Touchscreen Controller
• Intuitive, comprehensive, and easy-to-understand
• Virtually comprehensible safety information and cabinet alarms via 3D BSC diagram
• Defined details of alarm types with clear instructions for proper intervention
• Centered and angled down for easy reach & viewing
• Selectable Quickstart mode for fast operation

Dimmable LED
• Adjustable work zone brightness
• Ideal light intensity of 1000 lux
• Saves energy and optimizes work comfort

Ergonomic Features
• 200 mm (8"") sash opening
• Frameless, shatterproof, and UV-absorbing tempered glass
• Motorized window
• Aerosol tight window seal

Tiltable Sash
• For easy cleaning of the inner sash glass

USB Port and Remote Modbus
• USB port to access cabinet data log and BMS connectivity
• Newly integrated Remote Modbus feature for users to securely access the cabinet remotely from external devices.

Cabinet Construction
• E Series: - Tempered Glass Side walls - increases visibility and prevents the operator from experiencing a ""boxed-in"" feeling Multi-piece work tray, autoclavable.
• Tempered Glass Side walls - increases visibility and prevents the operator from experiencing a ""boxed-in"" feeling
• Multi-piece work tray, autoclavable

Green Product
• Equipped with energy-efficient Dual DC ECM that allows up to 70% energy savings vs AC motor
• Extremely low energy consumption
• Standby mode allows reduced power consumption

ULPA Filter
• 10x filtration efficiency compared to the HEPA filter
• Creates ISO Class 3 work zone instead of industry-standard, ISO Class 5
• Same 10 years filter life and replacement cost as HEPA filters

Isocide™ Antimicrobial Powder Coating
• Eliminates 99.9% of surface bacteria within 24 hours of exposure

Technical data:
• Average airflow velocity: inflow 0.45 m/s, downflow 0.32 m/s
• Usable work area: 0.93 m2
%
KBF PRO 470 plant growth chamber with LED plant light module
The Binder KBF PRO 470 climate chamber, with its extended temperature and humidity range, combined with the Binder LED light module, can be easily adapted for plant growth applications. The system provides precise control throughout all growth stages, featuring three independent light channels and real-time programming options to perfectly meet the unique needs of plants.

Package contents

Binder KBF PRO 260 standard climate chamber with extended temperature and humidity range

• Temperature range: +10°C to +50°C
• Humidity range: 10% to 90% relative humidity (RH)
• Proven APT.line™ preheating chamber technology
• Energy-efficient cooling with modern inverter cooling unit
• Cooling with environmentally friendly R-290 refrigerant
• Door heating to prevent condensation
• Adjustable fan speed
• Humidity control with capacitive humidity sensor and rapid steam humidification
• Housing design with HIT technology
• Stainless steel interior
• Interior doors made of safety glass with metal oxide coating
• Two stainless steel shelves with telescopic rails
• Large access port with silicone plug
• Floor-standing design with sturdy twin casters and front brakes
• Stackable desktop models, up to 130 liters in capacity
• Intuitive touch-screen controller with time-segmented and real-time programming
• Internal data logger, measured values can be read in open format via USB
• Independent Class 3.3 temperature safety device (DIN 12880) with visual and acoustic alarms
• Device self-test with comprehensive status analysis
• Data interfaces: Ethernet, USB
• BINDER Multi Management Software APT-COM™ basic version

Binder light module for plant growth

• 16 LED light strips with mounting clips
• Lighting control unit with program controller, power supply, and fresh air pump
• Mounting rails and screws for securing the lighting control unit
• Special silicone foam plugs for sealing the access port
• Cabling

Control unit functions

• Three light channels, individually adjustable from 10% to 100%
• Real-time programming
• Twilight function
• Ventilation function
%
Miele PLW 7111 [S-1011 EL DU SC DP] SST SlimLine laboratory glasswasher
SlimLine laboratory glasswasher, with electric heating, hot air drying, drain pump, capacitor
• Construction type: Freestanding, 1 glazed hinged door
• Front/back/side panels: Stainless Steel
• Number of wash levels: 3
• Loading and unloading with telescopic runners
• Electric door lock
• Buzzer, acoustic signal at end of programme
Control
• Control type: TouchControl, full-touch colour display
• Freely programmable
• Selectable display languages
Standard electrical connection
• Total rated load in kW: 10,10
Water connection/drainage
• Cold water [number]: 1
• Hot water [number]: 1
• DI water [number]: 1
• Required flow pressure in kPa: 100-600
Drying unit
• Air throughput in m³/h: 130
• HEPA filter class H14, HEPA filter filtration efficiency (DIN EN 1822) in %: 99,99
Emissions data
• Heat dissipation into the room in MJ/h: 0,80
Features
• 2 integrated diaphragm dispenser pumps for liquid media
• 2 additional integrated dispenser pumps
• EasyLoad
• Setting options for process chemicals (3 x 5 l)
• Wash cabinet made of high-quality stainless steel (1.4404/316L), electropolished
• Variable-speed pump
• SlimLine mobile plinth
• Chamber lighting
Connection options
• Ethernet, USB interface
• Peak-load negotiation / energy management
%
Binder KBF 720 Constant climate chambers with a large temperature / humidity range
The proven specialist for reliable ICH stability tests in the pharmaceutical industry: the KBF masters all long-term tests, accelerated tests and stress tests. It fulfills all important ICH requirements, from precision to programming and documentation. With flexible water supply options for all installation locations. In addition, the new KBF consumes up to 40 % less energy than its predecessor. With optional light modules, the KBF can be converted into an ICH photostability chamber and a plant growth chamber.

Product features

• Temperature range: 0°C to +70°C
• Humidity range: 10% to 80% RH
• Proven APT.line™ preheating chamber technology
• Up to 40% lower energy consumption compared to the previous model
• Energy-efficient cooling with modern inverter cooling unit
• Cooling with climate-neutral R-600a refrigerant
• Door heating to prevent condensation
• Adjustable fan speed
• Humidity regulation with capacitive humidity sensor and responsive steam humidification
• Housing design with HIT technology
• Stainless-steel inner chamber
• Inner doors made of metal oxide-coated safety glass
• Two racks made of stainless steel
• Large access port with silicone plug
• Floor-standing units featuring robust twin casters with brakes at the front
• Stackable tabletop units with a volume of up to 130 liters
• Intuitive touchscreen controller with time-segment and real-time programming
• Ergonomically adjustable control terminal (for units with a volume of 470 liters and above)
• Signal triangle with light-up status display (for units with a volume of 470 liters and above)
• Internal data logger, measured values can be read out in open format via USB Class 3.3 independent temperature safety device (DIN 12880) with visual and acoustic alarms
• Unit self-test for comprehensive status analysis
• Data interfaces: Ethernet, USB
• BINDER Multi Management Software APT-COM™ basic edition
• Optional light modules for ICH photostability testing (for models 260, 470, 720)
• Optional LED light modules for plant growth (for models from 260)
%
Binder KB 470 Cooling incubators, with a large temperature range
The powerful virtuoso in cooling incubators for microorganisms: KB units are able to incubate with exceptional precision even when fully loaded, feature a hot-air disinfection routine, and can be programmed for weekend operation with ease. The new KB unit consumes as much as 40% less energy than the previous model.

IMPORTANT FEATURES

• Temperature range: 0°C to +70°C
• Proven APT.line™ preheating chamber technology
• Up to 40% lower energy consumption compared to the previous model
• Energy-efficient cooling with modern inverter cooling unit
• Cooling with climate-neutral R-600a refrigerant
• Door heating to prevent condensation
• Housing design with HIT technology
• Interior made completely of stainless steel
• Inner doors made of metal oxide-coated safety glass
• Two racks made of stainless steel
• Large access port with silicone plug
• Floor-standing units featuring robust twin casters with brakes at the front
• Stackable tabletop units with a volume of up to 130 liters
• Simple programming of a second set temperature value
• Internal data logger, measured values can be read out in open format via USB
• Class 3.3 independent temperature safety device (DIN 12880) with visual and acoustic alarms
• Unit self-test for comprehensive status analysis
• Data interfaces: Ethernet, USB
%
Kühner SB2500-Z single-use bioreactor
Orbital shaken bioreactor for single-use bags with a working volume up to 2500 litres
The next generation of manufacturing-scale orbital shaken bioreactor (OSB) SB2500-Z is now available for the cultivation of human, mammalian, plant, and insect cells in a single-use bag. The bioreactor system has a working volume of 500 to 2500 liters. This user-friendly system has comparatively short set-up times and can be easily deployed in production. The SB2500-Z complies with GMP requirements and regulations.

Performance characteristics

• Large range of working volume: 500-2500 L

• Cultivation of human, mammalian, plant, and insect cells

• User-friendly & fast and simple set-up

• 3D single-use bag

• Trouble-free scale-up

• Online measurement and control of pH and DO

• Qualification for GMP production processes

Single-use bag for a fast and simple set up
The gamma irradiated 3D single-use bag for the Kühner orbital shaken bioreactor requires no additional mixing device and is therefore light and easy to handle. This enables quick set up times and eliminates elaborate cleaning and sterilizing procedures. The single-use bag has a working volume from 500 liters up to 2500 liters. Various ports are incorporated to allow inoculation, feeding, sampling, pH regulation, and harvesting. Two optical sensors each for pH and for DO measurement are built in. Customized bags are easily available on request.

Orbital motion
The orbital motion of the SB2500-Z ensures efficient liquid mixing with low localized power input per unit volume. It allows high oxygen transfer rates with low shear forces. Mechanical stress on the cells is reduced thanks to bubble-free surface gassing with almost no frothing.

Trouble free scale-up
Another advantage of the SB2500-Z is the easy scale-up from microtiter plates over shake flasks to shaken bioreactors all the way up to 2500 liters. The consistent hydro-dynamics of shaken bioreactors provide reproducible cultivation conditions throughout the scaling process.

Good Manufacturing Practice (GMP) and IQ/OQ Documentation
The SB2500-Z complies with GMP requirements and regulations. Kuhner products have established a global reputation of excellence under GMP requirements. Documentation, development and production along with the full life cycle of our products are continuously enhanced to match the requirements of 21 CFR and GAMP 5.
IQ-OQ (Installation Qualification and Operation Qualification), an equipment qualification required for GMP procedures, is available from Kuhner and qualification services can also be provided at the customer's premises.
We subject all our shaking machines to an elaborate final test before delivery and send the test protocols to our customers.

Reliable and monitored drive system
The shaking unit of the SB2500-Z uses a robust and long-lasting drive system which guarantees accurate control of the orbital speed and low energy consumption. The drive system (agitation) requires zero bag penetrations and runs without belts, meaning no abrasion or particle generation, an important factor for production processes in cleanrooms. Motor-specific parameters are constantly monitored, allowing for predictive maintenance and failure prevention. The entire drive unit may be exchanged with a process in place in less than 2 hours.

Control unit
The bespoke control unit, designed by Kuhner, uses the latest touch-screen technology and Siemens SCADA for data recording, calibration, programming and controlling. Technical controls for 21 CFR Part 11 compliance are built into the software.

Temperature regulation
The SB2500-Z can be electrically heated or (optionally) cooled. If cooling is chosen as an option, a cooling ring is embedded in the base plate of the SB2500-Z. Cooling is achieved by connecting an external cooling device. An integrated valve, controlled by the software, regulates the set point temperature. Temperature ramps are easily programmed and processed.

Online measurement and control of pH and DO (dissolved oxygen)
The single use bag has built in pre-calibrated, optical sensors for pH and DO (two of each). The duplex online measurement of both parameters in the medium ensures greater process safety. The pH value can be controlled by the addition of acid/base via peristaltic pumps or stabilized via dosage of CO2. To control the DO, the gas flow of the inlet gas can be increased or decreased, the percentage of oxygen in the inlet gas can be varied (via the gas mixing device), and the shaker speed can be adjusted.

Pumping system
There are three peristaltic pumps, which can be placed external, mobile and can be controlled by the bioreactor software. The control unit incorporates two smaller and one large peristaltic pump. This enables simple regulation of the pH value, feeding and the transfer of the culture media for downstream processing.

Gas mixing (FlowCon)
The SB2500-Z has an integrated gas mixing device (FlowCon). Whether stabilizing the pH with CO2, or preventing low dissolved oxygen concentrations, the gas mixer meets all user needs. Four mass flow controllers ensure highly accurate and reproducible gas mixing. An integrated pressure sensor prevents over pressure in the bioreactor by reducing the gas flow in the first step and shutting off the gas flow in the second step. Step limits can be freely programmed by the user. There is also another pressure sensor directly connected to the bag via the filter. Integrated gas filters ensure interference free and long operating times for the FlowCon.

Filter heater
A height adjustable filter heater, with up to two exhaust filters, is installed above the vessel. Special emphasis has been placed on developing a user-friendly unit. The filter heater combats any water vapor condensation in the outlet air which might cause the membranes to block. The temperature is monitored and controlled by the Siemens SCADA software of the control unit.