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Orbital shaken bioreactor for single-use bags

The SB50-X is an orbital shaken bioreactor for the cultivation of human, mammalian and plant cells in a single-use bag. A working volume from 15 litres up to 50 litres for the SB50-X ensures easy scale-up from microtiter plates to shaking flasks and all the way up to 200 litres. The SB50-X can be used in research, process development or production.
The SB50-X was developed and tested in collaboration with ExcellGene SA (Monthey, Switzerland) and the Swiss Federal Institutes of Technology EPFL (Lausanne, Switzerland).

Performance characteristics

• Large capacity (50L working volume)

• Single use bioreactor system

• Cultivation of human, mammalian and plant cells

• Fast, simple set up

• Easy scale-up

• Online measurement of pH and DO

Single-use bag for fast and simple set up
The cylindrical vessel accepts a single-use bag. This bag requires no additional mixing device, enables quick set up times and eliminates elaborate cleaning and sterilising procedures. Various ports are incorporated to allow feeding, inoculation, harvesting and sampling. The bag has built in optical sensors for pH and DO.

Orbital motion
The orbital motion of the SB50-X ensures efficient liquid mixing. It allows high oxygen transfer rates with low shear forces. Mechanical stress on the cells is reduced thanks to bubble-free surface gassing with almost no frothing. This motion is particularly suitable for microcarrier cultivation. The SB50-X uses the unique Kuhner direct drive which provides accurate control of the orbital speed.

Trouble free scale-up
The SB50-X fills a gap in the scale-up chain from microtiter plates all the way up to 200 litres. The consistent hydro-dynamics of shaken bioreactors provide reproducible cultivation conditions throughout the volume range. The culture from the SB50-X can also serve as preculture or inoculum for the SB200-X.

Control unit and online measurement
The bespoke control unit, designed by Kuhner, uses the latest touch-screen technology and Kuhner Insight software for data recording, calibration, programming and controlling. Technical controls for 21 CFR Part 11 compliance are built into the software.
The SB50-X can be heated or cooled. Temperature ramps are easily programmed and processed.
Online measurement of each parameter (dissolved oxygen and pH-value in the medium) is available.

Pumping system
The control unit incorporates two small and one big peristaltic pump. This enables simple regulation of the pH value, feeding and the transfer of the culture media (scale-up or processing).

Gas mixing
The SB50-X has an integrated gas mixing device (FlowCon).
Whether stabilizing the pH with CO2, or preventing low dissolved oxygen concentrations, the gas mixer meets all user needs. Four mass flow controllers ensure highly accurate and reproducible gas mixing. An integrated pressure sensor prevents over pressure in the bioreactor by reducing the gas flow in the first step (1. limit) and shutting off the gas flow in the second step (2. limit). Step limits can be freely programmed by the user. Integrated air filters and back pressure valves ensure interference free and long operating times for the FlowCon.

Filter heater
A height adjustable filter heater, with up to two exhaust filters, is installed above the cylindrical vessel. Special emphasis has been placed on developing a user friendly unit. The filter heater combats any water vapour condensation in the outlet air which might cause the membranes to block. The temperature is monitored and controlled by Kuhner Insight software.

Detailed technical data can be found in the product catalog.

This laboratory freezer has 5 vertically adjustable and plastic coated shelves which rest on mountings. This laboratory freezer can also be fitted with wire baskets and aluminium trays on runners at a surcharge.
• PRO-ACTIVE- Control:
Permanent, proactive monitoring of the performance data and alerts in the case of deviations – so that you can take countermeasures in good time before a fault threatens your chilled goods; world´s most accurate temperature control in refrigerated areas thanks to two standard PT-1000 sensors
• 5 shelves, height-adjustable
• Castors
• Re-circulating air cooling
• Explosion proof interior (LABEX®-Intrinsic Safety)
• Additional warning in case of power failure (optical and acoustic)
• Optimized ventilation plates to minimize interior temperature differences
• Automatic defrosting
• Meltwater tray for manual emptying
• Rapid freezing cycle
• Easy-to-read LED temperature display
• Easy accessible control panel with key switch
• Micro-processor controlled temperature and thawing regulation to maximize temperature stability
• Minimum/maximum temperature memory
• Data documentation can be read via USB interface with KIRSCH Datanet software.
• Potential free contact for alarm transmission
• Lockable door
Options
• Adjustable feet to compensate for uneven floors.
• Compressor for 60 Hz operation
• Additional shelves on mountings or support rails
• Aluminium trays with support rails, 60 x 65 x 2,5(w x d x h in cm)
• Baskets with support rails, 60 x 65 x 10 (w x d x h in cm)
• Cooling machine with cold water connection
• GSM-Module
• PC-KIT-NET (Network capable version)
• Pen-recording thermometer for placing loosely inside appliance with waxed paper strips
• Disc-type pen-recording thermometer with 7-day measuring cycle with 100 recording discs and 5 felt tip pens
• Temperature probe PT 100 or PT 1000,
• 4 wire sensor, class 1/3 B, incl. measuring flask incorporated
Technical specifications
• Adjustable feet to compensate for uneven floors.
• Compressor for 60 Hz operation
• Additional shelves on mountings or support rails
• Aluminium trays with support rails, 60 x 65 x 2,5(w x d x h in cm)
• Baskets with support rails, 60 x 65 x 10 (w x d x h in cm)
• Cooling machine with cold water connection
• GSM-Module
• PC-KIT-NET (Network capable version)
• Pen-recording thermometer for placing loosely inside appliance with waxed paper strips
• Disc-type pen-recording thermometer with 7-day measuring cycle with 100 recording discs and 5 felt tip pens
• Temperature probe PT 100 or PT 1000,
• 4 wire sensor, class 1/3 B, incl. measuring flask incorporated

The Pioneer PX combines essential weighing functionality with competitive performance, offering high accuracy and repeatability for applications in laboratory, industrial and education settings. The PX is affordably priced, and intuitively designed for intelligent operation with a second line display for additional information, and USB and RS232 connectivity for easy communication.
• Applications
Basic Weighing, Parts Counting, Percent Weighing, Animal Weighing, Density Determination
• Display
Backlit Liquid Crystal Display (LCD); Second line display for additional information or guidance (dot matrix)
• Operation
AC adapter (included)
• Communication
RS232 and USB device (included); GLP/GMP data output with real-time clock
• Construction
Metal base, plastic top housing, removable stainless steel pan, glass draftshield, integrated weigh-below-hook, security bracket, calibration lock and in-use cover
• Design Features
User-selectable environmental filters and brightness settings, auto-tare, auto-dim, user-selectable span calibration points, software lockout and reset menu, userselectable communication settings and data print options, user-definable project and user IDs, software overload/underload indicator, stability indicator, four operating languages

The Pioneer PX combines essential weighing functionality with competitive performance, offering high accuracy and repeatability for applications in laboratory, industrial and education settings. The PX is affordably priced, and intuitively designed for intelligent operation with a second line display for additional information, and USB and RS232 connectivity for easy communication.
• Applications
Basic Weighing, Parts Counting, Percent Weighing, Animal Weighing, Density Determination
• Display
Backlit Liquid Crystal Display (LCD); Second line display for additional information or guidance (dot matrix)
• Operation
AC adapter (included)
• Communication
RS232 and USB device (included); GLP/GMP data output with real-time clock
• Construction
Metal base, plastic top housing, removable stainless steel pan, glass draftshield, integrated weigh-below-hook, security bracket, calibration lock and in-use cover
• Design Features
User-selectable environmental filters and brightness settings, auto-tare, auto-dim, user-selectable span calibration points, software lockout and reset menu, userselectable communication settings and data print options, user-definable project and user IDs, software overload/underload indicator, stability indicator, four operating languages.

FRONTIER™5000 SERIES Multi-Pro Centrifuges
Powerful and Versatile Universal Centrifuges for Virtually Every Lab
Application
Frontier 5000 Multi-Pro Centrifuges are designed for universal use in virtually every application in research, industrial & clinical laboratories. Combine with our range of rotors & accessories for customized use in specific applications. Available in 9 models with capacities from 0.2 ml to 4 × 750 ml - and feature high speed performance at maximum volume, automatic rotor identification and safety features.
Standard Features Include
• Powerful Platform Offers Maximum Flexibility for a Range of Applications
Our multi-purpose centrifuges offer a high-speed centrifugation platform which can be customized to fit workflow needs using a wide variety of rotors and accessories.
• Intuitively Designed for User-Friendly Operation
The intuitive design of the centrifuges & accessories enable easy access to parameter settings, and quick rotation between applications. Features include automatic rotor recognition and backlit LCD.
• Solid Engineering Ensures Reliability and Durability
The performance of these centrifuges is propelled by German engineering, and high-quality components for reliable use. Constructed of chemical-resistant stainless steel to ensure durability in lab use.
• Increased Safety
With Built-in Protective Features Frontier 5000 Series is equipped with protective features, including automatic over-speed protection, imbalance detection and self-diagnostic system to ensure reliable use and operator safety.

BINDER VDL series safety vacuum drying chambers ensure maximum safety when drying organic solvents. Explosion-protected unit with classification according to ATEX directive 2014/34/EU: EX II 2/3/- G IIB T3 Gb/Gc/- X.
Benefits
• Fast, gentle drying
• Optimum heat transfer through large thermal conducting plates
• Safe working thanks to ATEX-compliant safety concept
• Also option of modular complete system with vacuum pump and pump chamber
Important characteristics
• Temperature range: +9 °C above ambient temperature to +110 °C
• ATEX conformity for units: EX II 2/3/- G IIB T3 Gb/Gc/- X
• Intuitive touchscreen controller with graphical pressure and temperature display
• Program-controlled drying monitoring with automatic ventilation at end of process
• Internal data logger, measured values can be read out in open format via USB
• Pressure control device for heating activated from < 100 mbar
• 2 aluminum expansion racks, can be custom-positioned
• Universal connection for ventilation with ambient air or inert gas
• Universal access port DN 16 - for the introduction of external measuring devices
• Shatterproof, spring-mounted safety glass panel
• Large viewing window
• Computer interface: Ethernet
Optional equipment
• Expansion racks - Choice of aluminum or stainless steel racks depending on the application requirements
• Analogue output for temperature and pressure signals - for external monitoring and evaluation of the process parameters, integration into in-house systems is possible
• Universal ventilation - Selection of different ventilation by air or inert gas
• Universal access port DN 40 - for the introduction of external measuring devices
• Multi Management Software APT-COM - Manage, record and document device parameters
• Services - extensive services ensure correct device function

BINDER’s VD series vacuum drying chambers deliver impressive performance through their precise temperature control and gentle drying. The patented expansion rack technology from BINDER also optimizes heat transfer. The shelves can be repositioned for flexible placement and the interior of the chamber is easy to clean.
Benefits
• Fast, gentle drying
• Optimum heat transfer through large thermal conducting plates
• Safe work thanks to proven safety concept
• Also option of modular complete system with vacuum pump and pump chamber
• Important characteristics
• Temperature range: +9 °C above ambient temperature to +220 °C
• Controller with digital display of pressure and temperature
• Program-controlled drying monitoring with automatic ventilation at end of process
• Internal data logger, measured values can be read out in open format via USB
• 1 aluminum expansion rack, can be custom-positioned
• Inert gas connection
• Universal access port DN 16 - for the introduction of external measuring devices
• Shatterproof, spring-mounted safety glass panel
• Large viewing window with option of interior lighting
• Computer interface: Ethernet
• 2 relay outputs, 24 V DC (max. 0.4 A)
Optional equipment
• Touchscreen Controller - Graphical display of main process parameter
• Expansion racks - Choice of aluminum or stainless steel racks depending on the application requirements
• Analogue output for temperature and pressure signals - for external monitoring and evaluation of the process parameters, integration into in-house systems is possible
• Universal ventilation - Selection of different ventilation by air or inert gas
• Universal access port DN 40 - for the introduction of external measuring devices
• Multi Management Software APT-COM - Manage, record and document device parameters
• Services - extensive services ensure correct device function

The new products in the Solid.Line impress with their tried-and-tested BINDER quality and reliability. They are suited to drying and heating. The attributes of the Solid.Line are geared towards the application in question and therefore used in research and quality assurance.
Benefits
• Easy handling
• Accurate temperature control
• Simple and ergonomic door opening
Important characteristics
• Temperature range: +10 °C above ambient temperature to +250 °C
• APT.line™ preheating chamber technology
• Forced convection
• Adjustable exhaust air flap
• Controller with timer function
• 1 chrome-plated rack, incl. shelf supports
• Class 2 integrated independent adjustable temperature safety device (DIN 12880) with visual alarm

BINDER heating chambers of the FED Avantgarde.Line series provide almost unlimited capacity and are particularly adaptable. With advanced timing functions and a controllable fan, temperature and convection conditions are easily controlled.
Benefits
• Best energy efficiency on the market
• Excellent temporal and spatial temperature accuracy
• USB connection for recording data
• Temperature range up to 300 °C
Important characteristics
• Temperature range: +10 °C above ambient temperature to +300 °C
• Up to 30% lower energy consumption compared to conventional units on the market
• High temperature accuracy thanks to APT.line™ technology
• Adjustable fan speed
• Controller with LCD display and enhanced time functions
• Electromechanical control of the exhaust air flap
• 2 chrome-plated racks
• Units up to 115 liters are stackable
• Class 2 integrated independent adjustable temperature safety device (DIN 12880) with visual alarm
• Ergonomic handle design
• Ethernet interface
• USB port for recording data

A BINDER FD series Avantgarde.Line heating oven is always used when fast drying and sterilization is required. Thanks to its fully homogeneous temperature distribution, quick dynamics and powerful fan, this heating oven saves valuable time.
Benefits
• Best energy efficiency on the market
• Excellent temporal and spatial temperature accuracy
• USB connection for recording data
• Temperature range up to +300 °C
Important characteristics
• Temperature range: +10 °C above ambient temperature to +300 °C
• High temperature accuracy thanks to APT.line™ technology
• Forced convection
• Controller with LCD display
• Electromechanical control of the exhaust air flap
• 2 chrome-plated racks
• Units up to 115 L are stackable
• Class 2 independent temperature safety device (DIN 12880) with visual temperature alarm
• Ergonomic handle design
• USB port for recording data

The new products in the Solid.Line impress with their tried-and-tested BINDER quality and reliability. They are suited to drying and heating. The attributes of the Solid.Line are geared towards the application in question and therefore used in research and quality assurance.
Benefits
• Easy handling
• Accurate temperature control
• Simple and ergonomic door opening
Important characteristics
• Temperature range: +7 °C above ambient temperature to +250 °C
• APT.line™ preheating chamber technology
• Natural convection
• Adjustable exhaust air flap
• Controller with timer function
• 1 chrome-plated rack, incl. shelf supports
• Class 2 integrated independent adjustable temperature safety device (DIN 12880) with visual alarm

The strengths of a BINDER ED series drying chamber include routine drying and sterilization tasks up to 300 °C. Thanks to the natural convection, all thermal processes which use this drying chamber are highly efficient. The ED series ensures fast, uniform drying.
Benefits
• Best energy efficiency on the market
• Excellent temporal and spatial temperature accuracy
• USB connection for recording data
• Temperature range up to +300 °C
Important characteristics
• Temperature range: +5 °C above ambient temperature to +300 °C
• Up to 30% lower energy consumption compared to conventional units on the market
• High temperature accuracy thanks to APT.line™ technology
• Natural convection
• Controller with LCD display
• Electromechanical control of the exhaust air flap
• 2 chrome-plated racks
• Units up to 115 liters are stackable
• Class 2 integrated independent adjustable temperature safety device (DIN 12880) with visual alarm
• Ergonomic handle design
• USB port for recording data

The BD Avantgarde.Line series is specially designed for gentle incubation of organisms, as well as conditioning of heat-sensitive media. The new design of the units and the homogeneous temperature distribution ensure the very best results.
Benefits
• Excellent temporal and spatial temperature accuracy
• High process reliability
• 100 °C disinfection routine
Important characteristics
• Temperature range: +5 °C above ambient temperature to +100 °C
• High temperature accuracy thanks to APT.line™ technology
• Natural convection
• Controller with LCD display
• Electromechanical control of the exhaust air flap
• Inner door made of tempered safety glass
• 2 chrome-plated racks
• Units up to 115 L are stackable
• Class 3.1 integrated independent temperature safety device (DIN 12880) with visual alarm
• Ergonomic handle design
• USB port for recording data

BINDER’s new Multi Management Software provides management, logging, programming, and documentation options, and much more. With features ranging from GLP-compliant logging to convenient program creation and management of up to 100 units, the APT-COM™ 4 can be used in all industries and makes complex work processes much easier.

Important characteristics

APT-COM™ 4 BASIC edition
• Administration of up to five connected units
• Log management (creating, deleting, archiving)
• Documentation of measured values
• Central overview of all units in both diagram and table form
• Graphical presentation of measured values
• Graphical/numerical program editor
• Manual export of measured values (CSV/PDF file)
• Multilingual user interface (German, English, French, Spanish, Italian)
• Optional program execution via APT-COM™
• Timer function
• Import of data from APT-COM™ 3
APT-COM™ 4 PROFESSIONAL edition
All the same functions as the BASIC edition and:
• Administration of up to 100 connected units at the same time
• Central overview of all units in a room plan
• Email-based alarm system
• Web server for displaying results
• User administration for multiple users and authorizations
• Automatic, time-managed export of measured values
• Reports for further processing/archiving
• Automatic/manual backup and recovery

Refrigerated circulators of the DYNEO series distinguish themselves with a great price-performance ratio. The instruments offer high heating/cooling capacities for short heat-up and cool-down times. The refrigerated circulators work precisely and reliably even at higher ambient temperatures up to +40 °C. Either in basic research, in material testing or in technical systems – the DYNEO refrigerated circulators offer functional solutions for every requirement and budget.
• Models suitable for internal and external applications
• Optimized cooling coil design provides more space in the bath
• Continuously adjustable, powerful pressure pump
• Supply pressure 0.7 bar
• Easy change-over from internal to external circulation and vice versa
• Large color TFT display, multi-lingual user interface
• Ease of use via central rotary dial
• Integrated programmer
• External Pt100 sensor connection
• USB data port
• RS232 interface or analog interfaces (optional)
• Built-in drain tap for easy and safe drainage

JULABO immersion coolers are ideal for counter-cooling in combination with heating circulators and for rapid cooling of fluids down to low temperatures. These units represent a budget-priced alternative to customary cooling with tap water and as a substitute for dry ice.
• User-friendly operation and handling
• Compact design, small footprint
• FT402, FT902 and FT903 with integrated temperature control and display as well as external Pt100 sensor (200 × 6 mm Ø, stainless steel)
• Environmentally friendly alternative to precious tap water
• Dry ice substitution

Refrigerated Circulators from the CORIO CP range are suitable for applications with a temperature range from -50°C to +200°C. The enhanced pump performance ensures they are suitable for easy temperature control tasks in combination with external applications.
• Models for internal and external applications
• Bright, white, easy-to-read display
• Very quiet
• Easy change-over from internal to external circulation and vice versa
• External pump connections (M16×1) pump capacity, infinitely adjustable
• USB interface
• R232 interface
• Space-saving cooling coil design provides more usable space in the bath tank
• Bath lid and drain tap included
• Removable ventilation grid
• Refrigeration unit without side vents
• System for low liquid level
• Class III (FL) according to DIN 12876-1
To adapt the CORIO Refrigerated / Heating Circulator to your individual application, we offer a comprehensive range of accessories (bath fluid, tubing, adapter and more)

Refrigerated / Heating Circulators of the CORIO series distinguish themselves with a great price-performance ratio. They are ideal for all standard tasks and routine work in laboratories and industry.
• Models for internal and external applications
• Bright, white, easy-to-read display
• Very quiet
• Easy change-over from internal to external circulation and vice versa
• External pump connections (M16×1)
• USB interface
• Space-saving cooling coil design provides more usable space in the bath tank
• Bath lid and drain tap included
• Removable ventilation grid
• Refrigeration unit without side vents
• Class III (FL) according to DIN 12876-1
To adapt the CORIO Refrigerated / Heating Circulator to your individual application, we offer a comprehensive range of accessories (bath fluid, tubing, adapter and more).

Liebherr offers refrigerators and freezers with a spark-free interior specifically for storing explosive and highly flammable substances in laboratories and in the chemical industry. The inner liners meet the safety requirements of EU Directive 2014/34/EU (ATEX) and have been tested according to the EN 1127-1, IEC 60079-0 and IEC 60079-15 standards by electro-suisse – SEV (Swiss association for electrical and power engineering and information technology), an approved ATEX conformity evaluation organisation.

Product features

• +2 °C SafetyDevice
If the temperature falls below +2 °C due to a malfunction, the SafetyDevice takes control, stabilising the temperature, activating the alarm and protecting the contents from freezing

• ±5 °C temperature stability
Sensitive substances cannot be subjected to large deviations from the set storage temperature. Liebherr freezers guarantee a temperature fluctuation of no more than ±5 °C, so that the valuable goods you store in them are optimally protected and their quality is preserved.

• Power failure info
Mains failure alarm after a power failure.

• Min./max. temperature log
The min./max. temperature log stores the minimum and maximum interior temperatures and shows on the display whether the storage temperatures were within the tolerance limits.

• Easy-to-clean interior
The inner liner made of fully recyclable, robust and odourless polystyrene is manufactured in one piece without joints. This makes it quick and easy to clean the large, rounded corners.

• Feedthrough for external sensors
An integrated opening allows a separate sensor to be connected for additional temperature monitoring without having to drill holes or break the door seal.

• Mechanical lock
Liebherr professional appliances are equipped with a mechanical lock and two keys. This ensures that unauthorized persons cannot access your valuable and sensitive stored goods.

• SmartMonitoring (optional)
The cloud-based digital solution continuously monitors and documents temperatures and alerts you immediately via email, text message or phone if any deviations occur

• Retrofittable WiFi/LAN interface
The retrofittable WiFi/LAN interface enables you to easily connect your appliances with Liebherr SmartMonitoring or existing local systems.

• Antimicrobial handle with opening mechanism
The smooth-turning handle contains special antimicrobial substances that make it particularly hygienic. Regular and time-consuming disinfection is not necessary

• Replaceable door seal
Save time and money: the insertable Liebherr door seals are easy to change. If a seal is damaged, you can replace it yourself without any tools. Contact Liebherr Customer Service to purchase replacements.

• Self-closing door < 90°
To make loading, unloading and cleaning easier, the appliance door stays open if opened by more than 90°. If the opening angle is less than 90°, it closes automatically for safety.

• SmartFrost
Where there’s no ice, there’s no need to defrost: SmartFrost greatly reduces the frost build-up in the interior and on stored products. Defrosting is required less often – and when it is necessary, it is made much easier by the smooth, easy-to-clean interior walls. The evaporator is embedded in foam insulation, ensuring high energy efficiency and uniform cooling.

with extremely powerful pressure/suction pump and intuitive touch display

As with all circulators from the MAGIO range, the refrigerated circulators stand out thanks to their premium quality, high performance and intuitive operation. The devices offer extra strong pressure and suction pumps, thus fulfilling the highest demands for temperature control of external applications. Whether in basic research, material testing or technical systems – the MAGIO refrigerated circulators offer high-tech solutions for high customer requirements.

Product features

• Ideal for demanding external applications
• Simple control of complex applications
• Continuously adjustable, extremely powerful pressure / suction pump
• Flow rate 16 ... 31 l / min, pressure 0.24 ... 0.92 bar, suction 0.03 ... 0.4 bar
• Large, high-resolution TFT touch display with multilingual user interface
• Parts being in contact with the medium made of stainless steel
• Integrated programmer ICC
• External Pt100 sensor connection
• Interfaces: Ethernet, Modbus TCP/IP, RS232,RS485, Stakei, USB
• Absolute temperature calibration: 10 Point Calibration
• Classification III according to DIN 12876-1